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![]() These findings suggest that disruptions in downstream signaling of hypocretin secondary to an intracranial mass effect might result in narcolepsy-cataplexy in dogs and that brain MRI should be strongly considered in sporadic cases of narcolepsy-cataplexy. Nine months after SRT, the dog developed clinical hyperadrenocorticism, which was successfully managed with trilostane. The Dachshund underwent stereotactic radiotherapy (SRT), which resulted in reduction in the mass and coincident resolution of the cataplectic attacks. The dog was also negative for the hypocretin receptor 2 gene mutation associated with narcolepsy in Dachshunds, ruling out familial narcolepsy. Cerebral spinal fluid hypocretin-1 levels were normal, indicating that tumor effect on the ventral lateral nucleus of the hypothalamus was not the cause of the dog's narcolepsy-cataplexy. A 6-year-old male neutered Dachshund had presented for acute onset of feeding-induced cataplexy and was found to have a pituitary macrotumor on magnetic resonance imaging (MRI). In this report, a pituitary mass is described as a unique cause of narcolepsy-cataplexy in a dog. Schmid, S Hodshon, A Olin, S Pfeiffer, I Hecht, Sįamilial narcolepsy secondary to breed-specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs. Pituitary Macrotumor Causing Narcolepsy-Cataplexy in a Dachshund. In narcolepsy, there appears to be a reversal of normal cerebral deactivation patterns, particularly involving the brainstem, during stages I and II sleep.« less During stages I and II sleep without REM, there were significant increases in mean hemispheric Fg and brainstem-cerebellar Fg, just the opposite of changes in normals. During REMmore » sleep, mean hemispheric Fg increased concurrently with large increases in brainstem-cerebellar region flow. In patients with narcolepsy, mean hemispheric Fg while awake was 80.5 +- 13 ml per 100 gm brain per minute. Maximum regional blood flow decreases during sleep occurred in the brainstem-cerebellar, right inferior temporal, and bilateral frontal regions. In normals, mean hemispheric gray matter blood flow (Fg) during stages I and II sleep was significantly less than waking values. Electroencephalogram, electro-oculogram, and submental electromyogram were recorded simultaneously. Serial measurements of regional cerebral blood flow were made by the 135Xe inhalation method during the early stages of sleep and wakefulness in eight normal volunteers and 12 patients with narcolepsy. ![]() ![]() Our study offers a detailed picture of the distributed brain network involved during distinct stages of reward processing and shows for the first time, to our knowledge, how this network is affected in hypocretin-deficient narcoleptic patients.Narcolepsy: regional cerebral blood flow during sleep and wakefulnessĭOE Office of Scientific and Technical Information (OSTI.GOV) In addition, we found that activity in the nucleus accumbens and the ventral-medial prefrontal cortex correlated with disease duration, suggesting that an alternate neural circuit could be privileged over the years to control affective responses to emotional challenges and compensate for the lack of influence from ventral midbrain regions. ![]() By contrast, the patients showed abnormal activity increases in the amygdala and in dorsal striatum for positive outcomes. Our results reveal that activity in the dopaminergic ventral midbrain (ventral tegmental area) was not modulated in narcolepsy-cataplexy patients during high reward expectancy (unlike controls), and that ventral striatum activity was reduced during winning. We statistically compared the patients' data with those obtained in a group of 12 healthy matched controls. We used functional magnetic resonance imaging in 12 unmedicated patients with narcolepsy-cataplexy to measure the neural responses to expectancy and experience of monetary gains and losses. Here, we aim to test whether narcoleptic patients show an abnormal pattern of brain activity during reward processing. In humans, the loss of hypocretin-containing neurons results in a major sleep-wake disorder called narcolepsy-cataplexy, which is associated with emotional disturbances. Recent animal research suggests that hypocretins may also influence reward-related behaviors. Hypothalamic hypocretins (or orexins) regulate energy metabolism and arousal maintenance. ![]() What it does provide, however, is a way to look at our organization’s overall service management capabilities, understand how effectively we’re delivering great products and services to our customers, and come away with several actionable improvement ideas. As a collection of best practices, the ITIL framework does not provide a “playbook” or a strict set of standards. For several of our clients, having an Axelos ITIL Maturity Model certificate is way to establish and/or deepen trust with their customers.Īlthough the ITIL Maturity Model is based on ITIL 4 concepts, it is important to note that the assessment does not specifically evaluate an organization’s adoption of or adherence to ITIL guidance. Additionally, leaders can leverage the model to track progress of existing improvement initiatives, benchmark their results against similar organizations, and receive a formal certification from Axelos on the organization’s maturity level. ![]() With that said, the difference between the assessments we’ve traditional performed for clients and the new ITIL 4 Maturity Model is that, in addition to being able to leverage the collective expertise of a team of experienced consultants, the ITIL Maturity Model defines specific, objective, and standardized criteria by which to assess a team’s processes and practices as well as the larger ecosystem, making the entire assessment much less subjective in nature.Īnother key reason to use the ITIL Maturity Model is to support a team’s continual improvement efforts by identifying areas where the organization is weak and where improvements can yield the greatest benefit. We’ve developed our assessment methods over the years from helping our clients address their specific organizational challenges and goals. So, how is the ITIL Maturity Model different from other maturity models? Over the last 15 years, our team has designed and delivered a wide range of assessments and maturity models for clients, ones that are more skills-based or leadership focused, ones that are more process-based, and others that look at how the wider organization is functioning. For example, we have several clients that have implemented ITIL v3 processes over the years and are using the ITIL Maturity Model to gain visibility into how their teams are working, identify both short- and long-term improvements, and more easily transition to an ITIL 4 mindset. ![]() The ITIL Maturity Model, released in September, is an IT service management (ITSM) assessment instrument that can be used by teams at any point in their ITSM journey. Ultimately, we discuss what differentiates the ITIL Maturity Model and how it can help IT leaders improve how their teams work. We will also provide details on related maturity models like the Capability Maturity Model Integration ( CMMI), Gartner Maturity Model, International Standards Organization 20000 ( ISO 20000), and the Digital Positioning Model, comparing them, and discussing when to consider each one. We examine the components of the model, the different types of assessments available, and how assessments are scored. ![]() We will also include examples from our own consulting work and experience as an AXELOS Consulting Partner (ACP). This article gives an overview of the new ITIL Maturity Model, the first of its kind from Axelos, the creators of ITIL 4. ![]() Get started for free with Homebase An in-depth breakdown of Homebase’s features and fees Homebase is an all-in-one HR app for small businesses with versatile scheduling, time tracking, and payroll features.ĭesigned with small businesses in mind, Homebase tailors all its features to hourly workers in a variety of industries. So, while you might not need to connect to other software now, they’re available for future use. You can add apps as and when you need them. Last, Homebase’s range of integrations gives you more flexibility. On the other hand, Time Clock Wizard’s per-employee pricing means it’s most suitable for very small teams or companies with larger budgets. Our per-location pricing system means your costs won’t balloon as you hire more workers. Homebase is also more well-suited for small businesses looking to grow. Homebase prioritizes hourly workers with features like the GPS time clock and team communication mobile app, while Time Clock Wizard has tools for office workers, like webcam clock in verification. The two platforms differ mostly in terms of their use cases. With that in mind, let’s dig deeper into what each app can do. How Homebase and Time Clock Wizard stack up against each otherĪlthough we think Homebase is the best all-around choice for your team management needs, the software that will suit your best depends on your specific business. That means you pay more to get less at the end of the day. And Homebase has more features to keep you compliant with labor laws, like a custom employee handbook service and professional HR advice on demand.Īnd despite its more limited features, Time Clock Wizard actually comes at a higher cost than Homebase. For example, Homebase scheduling gives you four different tools to create timetables, whereas Time Clock Wizard only has two. Many of our features are also more versatile than Time Clock Wizard’s. That means you can handle all your essential processes in one place instead of juggling different apps. ![]() Homebase not only provides features for scheduling, time tracking, and payroll but also has built-in chat and recruitment. When it comes to employee management, Homebase and Time Clock Wizard have some of the most complete tool kits on the market.īut Homebase is the only true all-in-one solution. Get started for free with Homebase Why choose Homebase over Time Clock Wizard in 2023? ![]() Players complete chapters in order to progress through the story. There are also environmental ways to kill or distract individuals players can use poison to spike coffee, pull switches to make a disco ball fall and break, cause a massive explosion at a gas station, pull a switch to cause scaffolding to fall down, cause fires, or set off fireworks. Agent 47 also has the 'Instinct' ability that lets the player monitor enemies more easily. Players may use pistols, bottles or bricks, assault rifles, shotguns, fiber-wire, or steel pipe against enemies if opting for the action-oriented approach, or avoid enemies altogether, not being seen, using disguises, blending into the environment, and only attacking the set target(s), if using the stealth-oriented approach. The players choose how to complete each level, taking branching paths to get to a target or location. Objectives can range from simply reaching the end of the level, to eliminating specific individuals. Presented from a third-person perspective, the gameplay centers around completing set objectives within a series of levels. Hitman: Absolution is a stealth game in which the player assumes the role of a hitman named Agent 47. Disguises allow players to gain access to previously restricted areas. Gameplay In this gameplay screenshot, Agent 47 is disguised as a policeman. Following Absolution's disappointing reception, the series received a soft reboot in 2016's Hitman, which despite being set in the same continuity as previous installments, returned to the more open-ended style of gameplay and featured a new storyline. As of March 2013, the game had sold over 3.6 million copies. ![]() ![]() However, many critics and players disliked the game for its narrative, issues with the disguise system, and the game’s linear structure as opposed to the open ended nature of previous installments. ![]() The game was met with a polarized reception upon release, with most of the praise focusing on its graphics, environments and locations, as well as the varied gameplay options. For the first time in the series, the game featured an online component called "Contracts", which allowed players to create their own custom objectives for any of the missions in the base game and share them with others. Ībsolution 's single-player campaign follows genetically engineered contract killer Agent 47 and his efforts to protect a similarly genetically enhanced teenage girl from various parties who wish to use her potential as an assassin for their own ends, including a private military company, several criminal syndicates, and 47's own former employers, the International Contract Agency (ICA). Interactive Entertainment released enhanced versions of Absolution and Blood Money for the PlayStation 4 and Xbox One as part of the Hitman HD Enhanced Collection. On, Hitman: Absolution – Elite Edition was released for OS X by Feral Interactive it contains all previously released downloadable content, including Hitman: Sniper Challenge, a "making of" documentary, and a 72-page artbook. The game was released on 20 November 2012 for Windows, PlayStation 3, and Xbox 360. Before release, the developers stated that Absolution would be easier to play and more accessible, while still retaining hardcore aspects of the franchise. It is the fifth installment in the Hitman series and the sequel to 2006's Hitman: Blood Money. Hitman: Absolution is a 2012 stealth video game developed by IO Interactive and published by Square Enix's European branch. ![]() Though Fat Emma is long-gone, Mars’s copycat bars are still Halloween favorites. ![]() Soon after, Frank Mars whipped up some of his own “Minnesota nougat” for the Milky Way and 3 Musketeers bars. Pendergast Candy Company, of Minneapolis, used too much egg white in its nougat recipe in the early 1900s and accidentally invented the Fat Emma bar, the first to used fluffy nougat and so-named because of its girth. If you’re on the hunt for nostalgic gum, though, you might be able to get your fix with Beemans, Black Jack, and Clove gums, all of which are still produced. Although it became famous in the ’60s with the “Teaberry shuffle” commercials featuring Herb Alpert & the Tijuana Brass, the gum had been around since the turn of the century. Clark’s Teaberry Gum (Clark Brothers Chewing Gum Company, The Saturday Evening Post, 1929)Ĭandy enthusiasts online have reported seeing Teaberry gum at specialty stores (even in the last year), but all other signs are pointing toward the wildly popular gum’s extinction. For years, the only alternative has been strawberry Broadway Rolls, but the company Iconic Candy has been working for years on a proper return of the Danish Ribbon. Danish Ribbonsĭanish Ribbons - or Delfa Rolls - were an imported strawberry licorice treat that candy lovers might remember seeing on shelves in the ’60s. ![]() The next best things might be U-No and Abba-Zaba bars, the still-produced candies out of Baffle’s original Oakland company, Cardinet. Finding an alternative to the Baffle Bar these days is a head-scratcher (though we welcome suggestions). Early ads suggested that hostesses slice a bar into pieces and arrange it on a plate for their next party. Inside its chocolate coating were walnuts, fudge, and some sort of jelly. Manufactured from around the 1920s to the ’70s, the Baffle Bar was a bit of a mystery “with all the tang of the great outdoors” and “zest that was born of a mountain wind,” hinting at its California origin. Richardson Brands, however, owns and produces Beechies, the Chiclets-like candy-coated gum Beech-Nut made years ago. You can’t find it - officially - anymore, unless you want to pay $37.49 for a decades-old pack on eBay. Beech-Nut gum was popular in the mid-century (and their peppermint flavor was “the pep-pep-peppiest one”). Subscribe Today Beech-Nut Gum (Beech-Nut Packing Company, The Saturday Evening Post, 1935)īeech-Nut strictly makes baby food now, but they used to be in the ham, marmalade, mustard, and chewing gum businesses. ![]() ![]() Since the length of a circumference of a circle equals to its radius multiplied by #2pi#, the full angle of #360^0# equals to #2pi# radians. This will give you the measurement in radians. Indeed, if we increase the radius while leaving the central angle the same, the bigger arc that our angle cuts from a bigger circle will still be in the same proportion to a bigger radius because of similarity, and our measure of an angle will be the same and independent of a circle. To convert from degrees to radians, multiply the number of degrees by /180. So, the ratio between an arc and a radius is a measure of a central angle in radians.įor this definition of the angle's measure in radians to be logically correct, it must be independent of a circle. If an angle is twice as big, the arc it cuts off the circle will be twice as long and the measure of this angle will be 2 radians. ) What is the Value of Cos 225 Degrees The value of cos 225 degrees in decimal is -0.707106781. If the length of an arc that this angle cuts off the circle equals to its radius, then, by definition, this angle's measure is 1 radian. Cos 225 in radians: cos (5/4) or cos (3.9269908. converting degrees to radians and vice versaCartesian Polar Coordinates Calculator. Imagine a circle and a central angle in it. ![]() None of these words: This must be used in conjunction with other options. You don’t need to include quotation marks hereĪny of these words: Will return results that include any of the words you enter, whether a tweet includes one or all of them This exact phrase: Will return tweets with the exact phrase you enter in the exact order you enter it. WordsĪll of these words: Will return tweets that include all of the words you enter Let’s go through each section to explain what does what. This obviously allows you to get super specific. If you fill out multiple boxes, you will only get results that match all the criteria you’ve set. Then you just need to fill out what you want to search for. Tweets containing technology conference" where the author's location is set to within 30 miles of New York City" Technology conference" near:"NYC" within:30mi" Tweets containing technology conference" where the author's location is set to New York City"įind words and phrases sent from a set distance around a location Tweets sent from to words and phrases sent from a specific location Tweets sent to tweets sent from one account to another Tweets sent by tweets sent to a specific account Tweets that contain technology" or "physics" unless they contain "games" or "console""įind mentions of Twitter that mention tweets sent by a specific account (technology OR "physics") -("games" OR "console")" Tweets that contain technology" or "physics" AND "space" or "rockets""įind words or phrases without specific words or phrases (technology" OR "physics") ("space" OR "rockets")" Tweets that contain technology" unless they contain "medical" as well"įind words or phrases in the same tweet as other specific words or phrases Tweets containing the exact words technology" or "tech news""įind words or phrases without other specific words included Check out the table below to see how they work: Twitter has a bunch of their own you can use with their search bar (Google has a load too). Search operators are just extra phrases or symbols you add to your search term to make them more exact. If you want to get way more specific you have two options: using search operators or Twitter’s advanced search. News: This will now list popular tweets related to your search term, but only if they include links to a news article (whether posted by the news outlet themselves or a user).īroadcasts: In this tab you can browse all of the live broadcasts related to your search term.Īnd that’s it for the basic search. Videos: This will list popular videos related to your search term. Photos: This will list popular photos related to your search term. People: A list of accounts that are related to your search term. Latest: This will give you a chronological list of all tweets that include your search term in the body, as a hashtag, or in the name of the account. It essentially lists all the popular tweets that either include your search term in the body of the tweet, as a hashtag, or in the name of the account. What would you be thinkin’, Jake?” Ozzie Walls, p. I think my kids need me at home a whole lot more than Parchman needs me. “It’s easy to say I would, but a man don’t know what he’d do. Jake tries to convince Carl Lee not to kill anyone, so Carl Lee asks Jake what he would do if the roles were reversed. If it was your little girl, and if it was two niggers, and you could get your hands on them, what would you do?”īefore Carl Lee kills Cobb and Willard, he consults Jake about the legal fallout and asks Jake if he will represent him after he kills them. Roark argues that the death penalty is barbaric and should never be used. Here, Jake argues over the efficacy of the death penalty with Ellen Roark. “Death is too good for them, much too good.” Jake, p. While it's difficult to say definitively what the "most horrible crime of all" is, Jake's argument proves powerful for many members of the jury. A child will have to contend with their expanding understanding of what has happened to them for the rest of their childhood and, on top of that, may suffer from PTSD. This is a line from Jake's closing argument, where he suggests that the long-term consequences of this particular crime, the rape of a child, are worse even than murder, because a child doesn't understand immediately what is happening to them or why it is happening. “Perhaps the most horrible crime of all is the violent rape of a child.” Jake, p. ![]() To act unafraid would be disingenuous, so, Lucien says, act afraid if you feel afraid. He faces the death penalty, and the outcome of the case determines whether he will live or die. ![]() ![]() The jury is also afraid, and Carl Lee is the most afraid of all. He encourages Jake to embrace fear and points out that he is not the only one in that courtroom who feels afraid. Here, Lucien prepares Jake to face the jury for the first time. Our famous cheeseburger topped with hash browns, bacon, a fried egg and served with American cheese, lettuce, tomato and mayonnaise. 14.99ġ/2 pound of meat: Twin patties served on toasted rye bread with grilled onions and Swiss cheese. Old fashioned 1/2 pound burger served with crisp bacon, a large scoop of Mac & Cheese, a slice of American cheese, lettuce, tomato, pickle, onion and mustard. Our newest addition to the burger family. Old fashioned 1/2 pound burger with twin patties, served with American cheese, lettuce, tomato, pickle, onion and mustard. Add bacon or a fried egg to any burger for 99¢ No frozen patty here! Burgers are served with your choice of homemade chips, fries or tater tots. Norma’s Cafe Burgers are made from fresh choice beef. Grilled chicken in honey mustard served with Swiss cheese, bacon, lettuce, tomato and mayonnaise. 13.99Īmerica’s favorite cheesy sandwich on Texas toast, grilled to perfection, served with a pickle spear. 12.99Ĭhicken fried chicken fried golden brown with crisp bacon, lettuce, tomato and mayonnaise on Texas Toast. ![]() 10.99Ĭhicken fried chicken dipped in Norma’s Cafe spicy buffalo sauce, served with lettuce, tomato and mayonnaise. ![]() 13.99Ī juicy, tender chicken breast grilled to perfection, served with lettuce, tomato and mayonnaise. Smoked turkey and ham served with crisp bacon, cheese, lettuce, tomato and mayonnaise. Add veggie or cup of soup for 1.49.Ĭrisp bacon on Texas toast, served with lettuce, tomato and mayonnaise. Served with your choice of homemade chips, fries or tater tots. |
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